By the mid-1960s, according to Hoffer, psychiatry was emphasising the use of neuroleptic drugs. Hoffer claims that he and like-minded researchers, calling themselves "orthomolecularists", were snubbed and became the victims of a conspiracy, with their reports rejected by scientific journals. In 1967, Hoffer resigned his academic and administrative positions, entered into private psychiatric practice in Saskatoon, Saskatchewan and created the Journal of Schizophrenia as a means of publishing articles rejected by mainstream journals. After several name changes, the journal was called the Journal of Orthomolecular Medicine in 1986. In 1976, Hoffer relocated to Victoria, British Columbia and continued with his private psychiatric practice until his retirement in 2005. Hoffer continued to provide nutritional consultations and served as editor of the Journal of Orthomolecular Medicine. He was also President of the Orthomolecular Vitamin Information Centre in Victoria, BC.
Hoffer died May 27, 2009 in Victoria, British Columbia, Canada.
